![]() ![]() Compounds that bind in the nucleic acid grooves have been especially attractive for therapeutic development since they are generally less mutagenic and less toxic than intercalators. ![]() T bps and this also hinders binding of cationic minor groove agents such as those shown in Figure 1, for example.The G♼ bps are also more electropositive than A ![]() The extra group sterically hinders most of the original minor groove agents from sliding deeply into the groove to interact with the edges of bps in the groove.
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